Green Avenger in the early 1900s, possibly having to dress as a man to avoid social stigma, and then deciding to do a 180 and go full suffragette city.
Green Avenger and her high school pals as the first superheroes in the setting...they have no rolemodels outside of fiction to look to, and no backstop if they fail against the villains.
Green Avenger born in feudal Japan.
Lady Groincrush has actual super-powers.
The Alarmbot was purchased by someone else, and by the time GA knew about it going rogue, it was Too Late. Now she fights the Rise of the Machines in a post-apocalyptic wasteland!