yes, different is better. I suggest to try and think of something on your own first. There are thousands of sonic and megaman comics out there, so don't do them... at least not much. If you make your own sprites that's a plus. I make sprites for my comic a bunch, and I try to be different by getting thousands of people I don't know to make cameos. Its a great place, isn't it?
I kill things. Would you like to be killed? I'll do it for free