I'm not sure I like the two by two yet, buts it's different, and that's not bad.
On the 04/02 some the the translucency made the text hard to read, mainly Mike's dialog in the first panel.
The character's have definately gotten more expressive in the faces. You've kept the pace going even in the downtime, which is so hard to do.
Right now I think Sinclair is my favorite character, I hope to see more of him and his investigative skills.
Have you ever played with Cel Shading? I think you're art has gotten to a point where Cel Shading would add a lot to it.